CD-sACE2 inclusion compounds: An effective treatment for coronavirus disease 2019 (COVID-19).
Identifieur interne : 000961 ( Main/Exploration ); précédent : 000960; suivant : 000962CD-sACE2 inclusion compounds: An effective treatment for coronavirus disease 2019 (COVID-19).
Auteurs : Pengfei Sun [République populaire de Chine] ; Xiaosheng Lu [République populaire de Chine] ; Chao Xu [République populaire de Chine] ; Yanjin Wang [République populaire de Chine] ; Wenjuan Sun [République populaire de Chine] ; Jianing Xi [République populaire de Chine]Source :
- Journal of medical virology [ 1096-9071 ] ; 2020.
Abstract
Coronaviruses are common human viruses and include the severe acute respiratory syndrome coronavirus (SARS-CoV), the middle east respiratory syndrome coronavirus and the SARS-CoV-2. Coronaviruses mainly bind to transmembrane receptor proteins on the human cell membrane through spike proteins (S-proteins), thus releasing the RNA of the virus into the interior of the host cell to cause an infection. In this article, we discuss the mechanism and production of cyclodextrin-soluble angiotensin-converting enzyme 2 (CD-sACE2) inclusion compounds in the treatment of SARS-CoV-2 infections by blocking S-proteins. On the basis of the current research evidence, we believe that CD-sACE2 inclusion compounds have the potential to treat COVID-19. We hope that our article can provide a theoretical basis for later experiments.
DOI: 10.1002/jmv.25804
PubMed: 32232976
Affiliations:
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last="Lu">Xiaosheng Lu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plastic Surgery, Affiliated Hospital of Weifang Medical University, Weifang, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plastic Surgery, Affiliated Hospital of Weifang Medical University, Weifang</wicri:regionArea><wicri:noRegion>Weifang</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Chao" sort="Xu, Chao" uniqKey="Xu C" first="Chao" last="Xu">Chao Xu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plastic Surgery, Zibo Central Hospital, Zibo, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plastic Surgery, Zibo Central Hospital, Zibo</wicri:regionArea><wicri:noRegion>Zibo</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yanjin" sort="Wang, Yanjin" uniqKey="Wang Y" first="Yanjin" last="Wang">Yanjin 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Coronaviruses mainly bind to transmembrane receptor proteins on the human cell membrane through spike proteins (S-proteins), thus releasing the RNA of the virus into the interior of the host cell to cause an infection. In this article, we discuss the mechanism and production of cyclodextrin-soluble angiotensin-converting enzyme 2 (CD-sACE2) inclusion compounds in the treatment of SARS-CoV-2 infections by blocking S-proteins. On the basis of the current research evidence, we believe that CD-sACE2 inclusion compounds have the potential to treat COVID-19. 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